【摘要】 目的评价氯氮平合并拉莫三嗪治疗难治性分裂症的疗效和安全性。方法68例难治性分裂症患者随机分为研究组和对照组,分别给予氯氮平合并拉莫三嗪、氯氮平治疗,疗程12周,采用阴性和阳性症状量表及副反应量表评定疗效和副反应。结果对照组显效率为16.7%,有效率为50.0%;研究组显效率40.0%,有效率76.7%,两组显效率和有效率均有显著性差异(P<0.01),两组副反应比较无差异(P>0.05)。结论氯氮平合用拉莫三嗪治疗难治性分裂症疗效优于单用氯氮平,副作用少。更多还原

【Abstract】 Objective To study the therapeutic and side effects of lamotrigine augmented with clozapine for patients with refractory schizophrenia.Methods A total of 68 patients with refractory schizophrenia were randomly divided into the groups treated with clozapine (the contrast group) or the lamotrigine augmented with clozapine (the study group) respectively .The course of treatment was 12 weeks. The patients were evaluated with PANSS for efficacy and TESS for side effects.Results The effective rate and improve rate of the study group were 40.0% and 76.7%, and those of the contrast group were 16.7% and 50.0%,there were significant differences between the two groups(P<0.01). While there was no significant difference of side effects between the two groups(P>0.05).Conclusion Lamotrigine augmented with clozapine is an efficacious and safe strategy for treating refractory schizophrenia.更多还原