【摘要】 目的:探讨内异康复栓直肠给药对子宫内膜异位症(EMT)大鼠异位和在位内膜组织形态学的不同影响。方法:建立大鼠EMT模型,随机设内异康复栓高、中剂量组、丹那唑组、丹莪妇康煎膏组、模型组、空白组,造模30天后连续给药30天,观察各组药物对EMT大鼠异位和在位内膜组织形态学的影响。结果:内异康复栓中剂量组和丹那唑组显著减少EMT大鼠异位内膜的腺体数目(P<0.05),内异康复栓高、中剂量组明显缩小EMT大鼠异位内膜被覆上皮面积,使被覆上皮厚度明显变薄,但对EMT大鼠在位内膜的腺体数目和面积无明显影响。结论:内异康复栓可促进异位病灶组织萎缩,而对在位内膜组织结构无明显影响。更多还原

【Abstract】 Objective: To explore the different effects of rectal administration of Neiyikangfu suppository(NYKFS) on the tissue morphology of ectopic and eutopic endometrium of endometriosis(EMT).Methods: EMT model was made in rats.These rats were randomly divided into six groups: high-dose group of NYKFS,middle-dose group of NYKFS,Danazol group,Dan’efukangjiangao(DEUKJG) group,model group and normal control group.After 30 days of the model establishment,the rats were given different medicines for 30 days.Then the effects of different treatments on the tissue morphology of ectopic and eutopic endometrium were observed.Results: Middle dose of NYKFS and Danazol capsule could obviously reduce the gland numbers in ectopic endometrium of EMT model rats(P<0.05).High dose and middle dose of NYKFS could markedly reduce the superposition epidermis areas and make the superposition epidermis thinner in ectopic endometrium(P<0.01),but they had no obvious influence on the gland numbers and areas in eutopic endometrium of EMT model rats.Conclusion: NYKFS can promote the atrophy of ectopic focus,and have no obvious effect on eutopic endometrium.更多还原