【摘要】 目的探讨建立焦虑障碍(AN)的多导睡眠图(PSG)模式。方法应用日本1518K多导睡眠生理仪,采用眼电图和下颌肌电图及脑电图技术,对25例AN患者和33名正常对照者(NC)进行PSG整夜监测。结果与NC组比较,AN组PSG主要有:REM睡眠潜伏期前移[NC组(87.8±11.7)分,AN组(59.9±19.7)分,P<0.01],醒觉时间增加[NC组(17.7±6.4)分,AN组(36.9±11.9)分,P<0.01],睡眠潜伏期延迟[NC组(19.9±9.8)分,AN组(37.7±16.7)分,P<0.01],睡眠效率下降[NC组(94.6±5.1)%,AN组(90.5±5.7)%,P<0.05],第1阶段睡眠[NC组(9.1±1.9)%,AN组(19.7±10.9)%,P<0.01]增高,第2阶段睡眠[NC组(56.2±4.7)%,AN组(47.7±22.3)%,P<0.05]降低。结论焦虑障碍患者有REM睡眠潜伏期前移、慢波睡眠S2降低等多项睡眠脑电指标的异常,应与神经生化结合进一步追踪研究。更多还原

【Abstract】 Objective To assess the changes in the whole night polysomnography(PSG) in patients with anxiety (AN).Methods The changes in the whole night PSG were recorded from 25 patients with anxiety disorders and 33 normal subjects by using Neurofax-1518K(Nihon Kohden) sleep instrument.Results Compared with normal subjects,anxiety patients showed significantly shortened REM latency[NC(87.8±11.7) min,AN(59.9±19.7) min,P<0.01],increased waking times[NC(17.7±6.4) min,AN(36.9±11.9) min,P<0.01],prolonged sleep latency[NC(19.9±9.8) min,AN(37.7±16.7) min,P<0.01],reduced sleep efficiency[NC(94.6±5.1)%,AN(90.5±5.7)%,P<0.05],increased stage 1 periods[NC(9.1±1.9)%,AN(19.7±10.9)%, P<0.01],and decreased stage 2 periods[NC(56.2±4.7)%,AN(47.7±22.3)%,P<0.05]. Conclusion Patients with anxiety disorders exhibited abnormality in shortened REM latency,and decreased slow wave sleep.Further study associated with neurochemistry need to be made.更多还原