【摘要】 目的探讨羊膜腔内灌注治疗胎儿生长受限的临床价值。方法采用B超引导下羊膜腔内灌注复方氨基酸溶液的方法治疗30例胎儿生长受限孕妇(观察组),同时采用母体静脉给药的方法,治疗70例胎儿生长受限孕妇(对照组)。了解羊膜腔内灌注治疗的安全性,并对两组治疗结局及围生儿预后进行对比性分析。结果观察组中30例孕妇共实施灌注治疗65次,其中62次为1次穿刺完成灌注,占95.38%,有3次为2次穿刺完成灌注,占4.62%;灌注术中未出现不良反应,无胎盘早剥、羊水栓塞、胎膜早破、穿刺感染等并发症。两组孕妇经不同途径给药治疗后比较,其子宫底高度(t=6.86,P<0.01)、胎儿双顶径(t=7.23,P<0.01)、胎儿腹围(t=5.58,P<0.05)、胎儿股骨长度(t=3.47,P<0.05)增长情况及新生儿出生体重(t=4.31,P<0.05)有显著性差异。结论经腹羊膜腔内灌注治疗胎儿生长受限是一种简便、可行、安全、有效的方法,可直接有效地促进胎儿生长发育,对改善围生儿预后,降低胎儿生长受限危重儿的发生,具有较高的临床应用价值。更多还原

【Abstract】 Objective To investigate clinical value of transabdominal intra-amniotic perfusion for treatment of fetal growth restriction(FGR).Methods Under direction of B-mode ultrasonography,compound aminophenol solution was perfused into the amniotic cavity of 30 pregnant women with FGR(observation group),while other 70 pregnant women with FGR were given intravenously compound aminophenol solution(control group).The safety of intra-amniotic perfusion should be guaranteed.The treatment outcomes and prognosis of the peri-neonates in the two groups were compared.Results 65 times of intra-amniotic perfusion were conducted for 30 pregnant women in the observation group,of which,62 times completed by once puncture,accounting for 95.38%,and other three times were completed by two-times puncture,accounting for 4.62%.No adverse effects were found and no complications such as placental abruption(premature separation of placenta),amniotic fluid embolism,premature rupture of fetal membranes,puncture infection occurred.In increments in height of fundus of uterus(t=6.86,P<0.01),fetal biparietal diameter(t=7.23,P<0.01),fetal abdominal circumference(t=5.58,P<0.05),fetal femoral length(t=3.47,P<0.05),and birth weight(t=4.31,P<0.05),there were significant differences between the two groups.Conclusion Trans-abdominal intra-amniotic perfusion for treatment of FGR is a simple,feasible,safe and effective method.It can promote growth and development of the fetus directly and effectively and is of higher application value for improving neonatal prognosis,and reducing incidence of critical neonates with FGR.更多还原