【摘要】 目的通过检测经症状自评量表评定为精神紧张、焦虑的产妇(观察组)和正常产妇(对照组)的血催产素和前列腺素E2在不同产程中的浓度,研究其与产程及妊娠结局的相关性。方法抽取140例观察组和60例对照组产妇在第一产程潜伏期、活跃期、第二产程、第三产程的血样,采用ELASA法测定血样中催产素和前列腺素E2的浓度,观察并记录产妇产程进展及结局、视觉模拟评分、产后出血量、新生儿Apgar评分和新生儿体重等,并进行相关的统计学分析。结果未发现精神紧张的产妇血催产素和前列腺素E2的浓度在各产程中与对照组有统计学上的差异,两组产妇在收入、视觉模拟评分、产后出血量等方面无显著性差异(均P>0.05)。教育程度在两组间有统计学意义(2χ=11.224,P=0.007<0.05);观察组有22.9%(32/140)因胎儿窘迫或产程停滞而行剖宫产终止妊娠,对照组有6.7%(4/60)以剖宫产终止妊娠,两组的剖宫产率相比,差异具有统计学意义(P=0.006<0.05)。结论精神因素对孕妇产程中催产素和前列腺素E2浓度的影响具有不确定性,有待于进一步研究。初产妇较经产妇而言,更易精神紧张。精神紧张的观察组产妇剖宫产率较对照组高,差异有显著性。更多还原

【Abstract】 Objective To investigate influences of psychological factors such as mental stress during pregnancy on serum levels of neuroendocriological factors such as oxytocin(OT),prostaglandin E2(PGE2) in labor and on process of labor,and to evaluate pregnancy outcomes of the pregnant women with mental stress.Methods 140 pregnant women with mental stress during their pregnancy were selected with Symptom Check List 90(SCL-90) as the observation group,and other 60 pregnant women without mental stress were selected as the controls.The blood samples of pregnant women in both observation group and control group were taken in latent phase and active phase,the second stage of labor and the third stage of labor respectively and the serum levels of OT and PGE2 were detected by using ELASA.The progress and outcomes of labor,visual stimulation score,amount of postpartum hemorrhage,and neonatal Apgar’s scores and birth weight were recorded and observed.The data were analyzed statistically.Results In serum levels of OT and PGE2 in each stage of labor there were no significant difference between the observation group and the control group.Also,there were no significant difference between the two groups in income of the pregnant women,visual stimulation score,amount of postpartum hemorrhage(all P>0.05).In education level of the pregnant women,there was a significant difference between the two groups(χ2=11.224,P=0.007<0.05).In the observation group,62.9%(88/140) of pregnant women with mental stress were nulliparae,and 22.9%(32/140) of them received cesarean section because of fetal distress or arrested labor,while the cesarean section rate in the control group was 6.7%(4/60),there was a significant difference between the two groups(P=0.006<0.05).ConclusionThe influences of psychological factors on serum levels of OT and PGE2 in different stages of labor of pregnant women are undetermined and need to be studied further.Nulliparae are more prone to suffer from mental distress than multiparae.The cesarean section rate of pregnant women with mental stress in the observation group is higher than that of those pregnant women without mental stress in the control group and the difference is significant.更多还原