【摘要】 目的了解入托儿童乙肝病毒感染状况及乙肝疫苗免疫效果,为防治工作提供依据。方法对2005~2007年共8 716名入托儿童抽取静脉血,采用酶联免疫吸附试验检测乙肝两对半,调查结果用SPSS11.0进行分析。结果儿童乙肝病毒总感染率为0.28%。乙肝病毒感染率2005年、2006年、2007年分别为0.13%、0.15%、0.46%,2007年与2005年、2006年比较差异均有统计学意义(χ2=13.8075、16.7643,均P<0.01);男童乙肝病毒感染率为0.30%,女童为0.25%,性别间差异无统计学意义(P>0.05)。乙肝疫苗接种率为97.23%,全程接种率为94.62%。抗-HBs总阳性率为63.84%,2005年、2006年、2007年分别为65.48%、70.68%、57.79%,各年份间差异有统计学意义(χ2=130.9123,P<0.01);男童抗-HBs阳性率为62.88%,女童为64.94%,性别间差异有统计学意义(χ2=4.0067,P<0.05)。乙肝两对半模式有12种,以抗-HBs阳性模式居首位。结论入托儿童乙肝病毒感染率较低,抗-HBs阳性率较高。2007年与前两年相比,乙肝病毒感染率有所升高,抗-HBs阳性率有所下降。必须重视儿童乙肝病毒的防治工作,进一步提高儿童的乙肝疫苗接种率。更多还原

【Abstract】 Objective To investigate status of HBV infection and anti-HBs level among kindergarten children so as to provide basis for treatment and prevention of the disease.Methods Venous blood samples of 8 716 children in kindergarten from 2005 to 2007 were taken and tested for five hepatitis B serological antigens and antibodies by means of enzyme-linked immunosorbent assay(ELISA).SPSS11.0 was used to analyze the results. Results The total HBV infection rate was 0.28% among 8 716 children and the HBV infection rates in the year 2005,2006 and 2007 were 0.13%,0.15% and 0.46% respectively.Compared with the year 2005 and the year 2006,the HBV infection rate among kindergarten children in the year 2007 was significantly higher and there was significant difference(χ2=13.8075,16.7643,both P<0.01).HBV infection rates among boys and girls were 0.30% and 0.25% respectively and there was no significant difference between the two genders(P>0.05).The total anti-HBs positive rate was 63.84% among 8 716 kindergarten children and the anti-HBs positive rates in the year 2005,2006 and 2007 were 65.48%,70.68% and 57.79% respectively and there was significant difference between the 3 years(χ2=130.9123,all P<0.01).The Anti-HBs positive rates among boys and girls were 62.88% and 64.94% respectively(P<0.01) and there was significant difference between the two genders(χ2=4.0067,P<0.05).There were 12 HBV infection modes observed,of which,positive AntiHBs was the most common mode.ConclusionHBV infection rate among kindergarten children is lower and Anti-HBs positive rate is higher.Compared with the year 2005 and the year 2006,the HBV infection rate in the year 2007 is increased while Anti-HBs positive rate is declined.In prevention and treatment of hepatitis B infection among children more attention should be paid and the hepatitis B vaccine inoculation rate should be improved further.更多还原