【摘要】 【目的】通过组织学与液基细胞学诊断结果的对比,评价液基细胞学诊断的准确性,分析误差产生的原因。【方法】回顾8 457例液基细胞学和798例组织学对照结果,计算不同级别假阴性率及假阳性率,并分析其产生的原因。【结果】798例中,细胞学低级别鳞状上皮内病变(LSIL)以上病变阳性率(21.05%)与组织学一级宫颈上皮内瘤变(C INΙ)以上病变阳性率(23.68%)比较无显著性差异(P>0.05);细胞学诊断各级假阴性率分别为LSIL 23.58%,高级别鳞状上皮内病变(HSIL)17.57%,鳞状细胞癌(SCC)0.00%,腺癌(AC)50.00%;各级假阳性率分别为LSIL 14.29%,HSIL 3.85%。【结论】液基细胞学检查是宫颈癌及癌前病变筛查的有效手段,取得满意的宫颈细胞标本对提高诊断准确性有重要意义。更多还原

【Abstract】 Objective The results of liquid-based cytology test(LBCT) and histological examination for cervical specimen were compared to evaluate the accuracy of LBCT and to analyze the cause of error.Methods A retrospective study was carried out in 8457 cervical specimens tested by LBCT and of which,798 were confirmed by histological examination.The false negative rate and the false positive rate in different degrees were calculated,and the causes of being false negative and positive were also analyzed.Results In 798 cervical specimens tested by histological examination,the cytological positive rate of low squamous intraepithelial lesion(LSIL) or severer lesion was 21.05%,and the histological positive rate of cervical intraepithelial neoplasia I(CINI) was 23.68%,the difference being insignificant(P>0.05).The cytological false negative rate was 23.58% for LSIL,17.57% for high squamous intraepithelial lesion(HSIL),0.00% for squamous cell cancer(SCC),and 50.00% for adeno-carcinoma(AC);the false positive rate was 14.29% for LSIL and 3.85% for HSIL.Conclusion Liquid-based cytology test is an effective method for the screening of cervical cancer and precancerous lesion.The high-quality cervical cell specimen is important to ensure the diagnosis accuracy.更多还原