【摘要】 目的测定碘-131治疗前甲亢患者血清TMAb、TGAb、TRAb,探讨其在治疗后致早发甲减的临床意义。方法根据甲状腺自身抗体水平对622例拟行碘-131治疗的甲亢患者进行分组。A组TMAb、TGAb、TRAb均阴性,54例;B组TMAb、TGAb阴性,TRAb阳性,176例;C组TMAb、TGAb阳性,TRAb阴性,78例;D组TMAb、TGAb、TRAb均阳性,314例。碘-131治疗后定期观察各组患者早发甲减的发生率。结果碘-131治疗1年后甲减发生率分别为A组11.11%,B组13.64%,C组26.92%,D组23.57%。A组与C、D组及B组与C、D组比较,P值均<0.05,差异有统计学意义;A组与B组及C组与D组比较差异无统计学意义(P值均>0.05)。结论TMAb、TGAb是碘-131治疗甲亢后致早发甲减的一个重要影响因素,而TRAb对其影响不大。更多还原

【Abstract】 Objective To observe the levels of TMAb,TGAb,TRAb in the serum of patients with hyperthyroidism before the treatment of radioiodine(131I)and investigate the clinical significance of the early hypothyroidism after 131I treatment.Methods According to the levels of thyroid auto-antibodies,622 patients with hyperthyroidism were divided into four groups:group A 54 cases with negative TMAb,TGAb and TRAb,group B 176 cases with nagative TMAb and TGAb and positive TRAb,group C 78 caese with positive TMAb,TGAb and negative TRAb,Group D,314 cases with positive TMAb TGAb and TRAb.The rate of early hypothyroidism were observed regularly after 131I therapy in each group.Results The rates of early hypothyroidism were 11.11% in group A,13.64% in group B,26.92% in group C and 23.57% in group D.Both the rates in group A and group B are lower than those in group C and group D(P<0.05).There is no difference in groups A.B.groups C and D(P>0.05).Conclusion The levels of TMAb,TGAb in are serum in an important influencing factor on the rate of the early hypothyroidism after 131I therapy for patients with hyperthyroidism,while the level of TRAb is of no importance.更多还原