【摘要】 目的探讨影响高危新生儿HBV慢性感染的相关因素。方法采用前瞻性和回顾性相结合的方法收集106份高危新生儿资料,其中HBV慢性感染者34例。对所有数据应用Logistic回归分析方法进行统计分析。结果孕妇的年龄、妊娠次数、HBeAg、分娩方式、父亲HBV感染、喂养方式等变量未进入新生儿慢性HBV感染统计学方程;孕妇的HBVDNA、新生儿免疫接种方法是影响新生儿慢性HBV感染方程的两个主要变量并有统计学意义。结论孕妇高水平HBVDNA是新生儿慢性HBV感染的危险因素,主动+被动免疫是新生儿慢性HBV感染的保护因素之一。更多还原

【Abstract】 Objective To investigated the risk factors of chronic HBV infection in high-risk infants. Method A total of 106 cases were collected by prospective and retrospective method. 34 of them were chronic HBV infection. All data was analyzed by Logistic regression analysis method. Result The data show that the variables not in the infants HBV infection equation include are the pregnant woman’s age, frequency of pregnancies, HBeAg, mode of delivery, HBV infection of father and feeding mode. The level of HBV DNA of the pregnant women and the method of vaccination are the major variables enter the infants HBV infection equation. Conclusion High level of HBV DNA of pregnant women is the major risk factor of the chronic HBV infection in high-risk infants and the method of initiative + passive vaccination is one of the protective measures.更多还原