【摘要】 目的探讨乙型肝炎病毒(HBV)感染与妊娠期肝内胆汁淤积症(ICP)的相关性。方法对我院产检孕妇进行乙型肝炎血清学测定,在本院随机选取HBV感染合并ICP者45例(A组)和单纯ICP者31例(B组),A组继续妊娠一个月后复查结果为C组;比较各组ICP发生的时间,总胆红素(TBIL)、直接胆红素(DBIL)、血清总胆汁酸(TBA)、丙氨酸氨基转移酶(ALT)及天门冬氨酸氨基转移酶(AST)的指标。结果A组各项指标均比B组升高(P<0.05),C组血清总胆汁酸(TBA)、丙氨酸氨基转移酶(ALT)及天门冬氨酸氨基转移酶(AST)较A组升高(P<0.05)。结论HBV感染合并ICP的孕妇肝功能损害较单纯ICP的孕妇加重,且并发症严重,要注意预防和治疗。更多还原

【Abstract】 Objective To investigate the correlation of hepatitis B virus(HBV) infection and intrahepatic cholestasis of pregnancy(ICP).Methods Serum samples from pregnant women in our hospital were examianed fro HBV,and 45 HBV patients comp.licated with ICP were chosen as group A,31 ICP patients were taken as control(group B).The patietns in group A reexamined a month after pregnancy were taken as group C.The total levels of bilirubin(TBIL),direct bilirubin(DBIL),total serum bile acid(TBA),alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in the three group s were determined.Results All the levels in group A were all higher than that of group B(P<0.05).The levels of TBA,ALT and AST in group C were higher than that of groujp B(P<0.05).Conclusion The lesions to liver of HBV-infected pregnant women complicated with ICP is more serious than that of simply ICP pregnant women.Thus preventive and treatment measures be taken.更多还原