【摘要】 目的观察服之灵对大鼠的长期毒性作用。方法以健康SD大白鼠为受试对象,随机分为对照组和服之灵高、低剂量组,服之灵分别按3g/kg、1.5g/kg体重灌胃给药,连续给药4wk。观察给药期间及停药后大鼠的一般状况、体重变化、血液学指标、血液生化学指标及组织器官等方面的变化。结果在连续给药4wk后,除极少数指标外,服之灵各剂量组大鼠的体重增长,外周血象、血液生化学指标、脏器系数及各组织器官的病理形态均未见有显著影响,与对照组基本一致。结论服之灵连续给药4wk,对SD大鼠的无毒反应剂量为1.5g/kg·d-1。更多还原

【Abstract】 Objective To observe the long-term toxicity of the Fuzhiling in rats.Methods The healthy SD rats were randomly divided into control group,large-doses group treated with 3g/kg of Fuzhiling and small-doses group treated with 1.5g/kg of Fuzhiling for a successive course of 4 weeks through oral administration.The general state and weight gain of the rats were observed.Routine blood biochemistry tests were performed and pathological changes of tissues were observed.Results There no marked effect in weight gain,periihperal blood and biochemical indexes,pathological changes in tissues and organs were observed in the rats treated with Fuzhiling as compared with that of control group.Conclusion There is no significant toxicity is observed in use of Fuzhiling for treatment of rats four weeks after administration and its maximal tolerance dosages for rats was 1.5g/kg·d-1.更多还原