【摘要】 目的探讨血浆中溶血磷脂酸(LPA)、超敏C-反应蛋白(Hs-CRP)的水平与缺血性脑血管病的关系。方法检测45例急性脑梗死患者、28例短暂性脑缺血发作患者血浆溶血磷脂酸和超敏C-反应蛋白浓度,并与46例健康体检者(正常对照组)比较。结果短暂性脑缺血发作组和急性脑梗死组血浆LPA含量分别为(9.31±3.12)μmol/L、(8.25±2.94)μmol/L均显著高于对照组(2.56±1.40)μmol/L,P<0.01。短暂性脑缺血发作组和急性脑梗死组血浆Hs-CRP含量分别为(10.58±3.45)mg/L、(12.36±3.74)mg/L均显著高于对照组(2.25±2.00)mg/L,P<0.01。结论溶血磷脂酸和超敏C-反应蛋白可能是缺血性脑血管病的独立危险因素之一,为缺血性心脑血管病的早期干预和防治提供了新的靶点。更多还原

【Abstract】 ObjectiveTo explore the relation level of plasma lysophosphatidic acid(LPA)、high sensitive C-reactive protein(Hs-CRP) and ischemic cerebrovascular disease. MethodsThe plasma levels of LPA and Hs-CRP were measured in 45 patients with Acute cerebral infarct(ACI),28 patients with Transient ischemic attack(TIA),and compared with 46 healthy contro1. ResultsThe level of LPA in the TIA and ACI group [(9.31±3.12)μmol/L、(8.25±2.94)umol/L] were significantly higher than that in the control group (2.56±1.40)μmol/L (P<0.01). The level of Hs-CRP in the TIA and ACI group[(10.58±3.45)、(12.36±3.74)] were significantly higher than that in the control group(2.25±2.00) mg/L (P<0.01). ConclusionsLPA and Hs-CRP may be a risk factor for ischemic cerebrovascular disease,provided the new targets for the early intervention and treatment of ischemic cerebrovascular diseases.更多还原