【摘要】 目的:综述鼻NK/T细胞淋巴瘤的诊断和治疗,探讨其更合理的治疗方案,为提高疗效改善患者预后提供理论依据。方法:应用计算机检索NC-BI Entrez PubMed和CNKI数据库2001-2007有关鼻NK/T细胞淋巴瘤的研究文章,检索词为"鼻NK/T细胞淋巴瘤、诊断、放疗和化疗",排除个案报道、重复研究类文章。共收集分析文献28篇。结果:NK/T细胞淋巴瘤在WHO新分类中被命名为"结外NK/T细胞淋巴瘤,鼻和鼻型",亚洲地区发病率明显高于西方国家。单纯化疗特别是含蒽环类的常规化疗方案疗效较差,非蒽环类化疗方案的结果具有显著优势。放疗为主的治疗结果优于单纯化疗。结论:ⅠE/ⅡE期患者应首选放疗,化疗可能更适合那些超腔组、非鼻侵袭型或晚期患者。最佳化疗方案可能不是含蒽环类方案,建议考虑非蒽环类方案。放化疗联合的综合治疗结果要好于单纯化疗,但与单纯放疗相比有一定争议,有待进一步进行多因素分层分析研究。更多还原

【Abstract】 OBJECTIVE:The literature of nasal natural killer cell(NK/T cell) lymphoma about diagnosis and therapy was reviewed,so as to investigate the reasonable therapeutic regimen and improve the patient’s curative effect and survival.METHODS: Articles on diagnosis and therapy of nasal natural killer cell(NK/T cell) lymphoma published between January 2001 and January 2007 were retrieved in NCBI Entrez PubMed and CHKI with the of "lymphoma,extranodal NK T cell,nasal cavity,diagnosis,drug therapy and radiotherapy".Twenty-eight articles were selected by primary choice.RESULTS: The nasal natural killer cell(NK/T cell) lymphoma is classified by the World Health Organization as extranodal NK/T-cell lymphoma,nasal type.It is prevalent in Asia,but exceptionally rare in western countries.The patients received chemotherapy alone,especially conventional anthracycline-based chemotherapy,have a poor response,and can not compare with the affection of nonanthracycline-based chemotherapy.The result of radiotherapy-based regiment shows a potential survival advantage contrasted with alone chemotherapy.CONCLUSIONS: The primary treatment of the patient with ⅠE/ⅡE stage should consist of radiotherapy.Chemotherapy could refer to the patients with the lesion beyond the nasal cavity,non-nasal type,and advanced stage.Conventional anthracycline-based chemotherapy can not campare with nonanthracycline-containing chemotherapy as the first-rate chemotherapy regimen.The consequence of the combined chemoradiotherapy surpasses the pure chemotherapy,nevertheless,it is still controversial as compared with pure radiotherapy.The analysis of subset by assessing prognostic factors should be performed.更多还原