【摘要】 目的:探讨叶酸对食管/贲门各级癌前病变的影响。方法:对河南省林州市食管癌(EC)高发区普查发现的384例食管/贲门正常及各级癌前病变居民进行为期1年的叶酸和安慰剂双盲对照研究,最终58位参与者(叶酸组30位,对照组28位)符合分析条件。结果:膳食补充药剂后叶酸组食管各级癌前病变好转率为50%(15/30),低于对照组的64%(18/28);无变化率为40%(12/30),高于对照组的21%(6/28);而恶化率为10%(3/30),低于对照组的14%(4/28),χ2=2.349,P>0.05。叶酸组贲门各级癌前病变好转率为20%(6/30),低于对照组的17%(5/28),无变化率为23%(7/30),低于对照组的50%(14/28);而恶化率为17%(5/30),低于对照组的21%(6/28),χ2=4.376,P>0.05。结论:未观察到叶酸干预对食管/贲门各级癌前病变有明显影响,尚需进一步扩大样本量验证。更多还原

【Abstract】 OBJECTIVE:To explore the effects of folate supplementation on esophageal and gastric cardia precancerous lesions. METHODS: Three hundred and eighty-four subjects with normal esophageal and gastric cardia and precancerous lesions in a high-risk for esophageal and gastric cardia cancer in Linzhou of Henan, were randomly divided into 2 groups to intake folate tablets and placebo pills, respectively for one year. At the end, 58 subjects were suitable for the analysis. RESULTS: After one year supplementation, the improved rate of esophageal precancerous lesions in the folate group (50%, 15/30) was lower than that in the placebo group (64%, 18/28), the unchanged rate in the folate group (40%, 12/30) was higher than that in the placebo group (21%, 6/28), and the deteriorated rate in the folate group (10%, 3/30) was lower than that in the placebo group (14%, 4/28), χ2=2.349, P>0.05. The improved rate of the gastric cardia precancerous lesions in the folate group (20%, 6/30) was lower than that in the placebo group (17%, 5/28), the unchanged and the deteriorated rates in the folate group (23%, 7/30; 17%, 5/30) were lower than those in the placebo group (50%, 14/28; 21%, 6/28), χ2=4.376, P>0.05. CONCLUSION: Folate supplementation does not show significant beneficial effects in alleviating esophageal and gastric cardia precancerous lesions in this study, to expand the study subjects to determine the effect.更多还原