【摘要】 蛋白酪氨酸激酶(protein tyrosine kinases,PTKs)是一类催化ATP上γ-磷酸转移到蛋白酪氨酸残基的激酶,能催化多种底物蛋白的酪氨酸残基磷酸化,在细胞生长、增殖及分化中具有重要作用。迄今发现的90余种PTKs具有癌基因功能,而Syk是目前发现的惟一具有抑癌作用的PTKs。近年来研究发现,Syk的表达与肿瘤的侵袭及转移密切相关。更多还原

【Abstract】 Protein tyrosine kinases(PTKs)are enzymes that catalyze the phosphorylation of tyrosyl residues.They are important in the processes of cell growth,proliferation and differentiation.About 90 PTKs have the functions of oncogenes,while Syk is the only one which has antineoplastic function.It’s found that there is a close correlation between the expression of Syk and tumor invasion and metastasis in recent researches.更多还原