【摘要】 目的:研究上皮性钙黏蛋白(E-Cad-herin)在人肝细胞癌(hepatocellular carcinoma,HCC)组织中的表达情况,探讨其与肝癌侵袭转移的关系。方法:选择56例有完整随访资料的HCC及相应癌旁组织标本、20例正常肝组织标本,用RT-PCR方法检测E-Cadherin mRNA的表达。结果:E-Cadherin在HCC组织中的表达显著低于癌旁组织和正常组织,P分别为0.016和0.003,而在癌旁组织和正常组织中的表达差异无统计学意义,P分别为0.076和0.082;E-Cadherin在肝癌组织中的表达与术后复发时间呈正相关,R2=0.887,P<0.05,与病理分级呈负相关,R2=0.823,P<0.05;癌组织中E-Cadherin表达与肝外转移呈负相关,R2=0.839,P<0.05。结论:E-Cadherin表达与肝癌的分化程度,侵袭转移能力,复发倾向相关,通过检测E-Cadherin表达将对肝癌临床转归的评估有一定指导意义。更多还原

【Abstract】 OBJECTIVE:To investigate the association between E-Cadherin expression and invasion and metastasis of hepatocellular carcinoma(HCC).METHODS:RT-PCR analysis technology were used to detect E-Cadherin mRNA expression in 56 paired HCC and non-HCC liver tissue samples and 20 normal liver tissue samples,respectively.RESULTS:The level of E-Cadherin expression in HCC was significantly lower than those in the adjacent non-HCC liver tissue and normal liver tissue(P were 0.016 and 0.003 respectively),but no difference was seen between the adjacent non-HCC liver tissue and normal liver tissue(P were 0.076 and 0.082 respectively).E-Cadherin expression in HCC had a positive correlation with the recurrence after the surgical treatment(R2=0.887,P<0.05),and an inverse correlation with pathological grade,R2=0.823,P<0.05.There was an inverse correlation between E-Cadherin expression and extrahepatic metastasis in HCC,R2=0.839,P<0.05.CONCLUSION:E-Cadherin has an correlation with the degree of tumor differentiation,capability of invasion and metastasis and tendency of recurrence,which may have some instructive significance for assessment of outcome of HCC.更多还原