【摘要】 目的:综合评价中国人群中乙型肝炎病毒(hepatitis B virus,HBV)、丙型肝炎病毒(hepatitis Cvirus,HCV)双重感染者发生肝细胞癌(hepatocellular carcinoma,HCC)的危险是否高于单独感染者。方法:检索中国生物医学数据库和Medline,获得1990~2006发表的有关中国人群HBV和HCV双重感染与HCC关系的研究结果,并进行Meta分析。所有文献均为病例对照研究。采用随机效应模型D-L法计算合并OR值及其95%CI。结果:共检索到符合要求的37篇文献,累计病例、对照数分别为4203和5642例。与未感染者相比,HBV、HCV单独感染发生HCC的合并优势比(OR)分别为20.91(95%CI:15.40~28.40)和10.60(95%CI:6.74~16.65);HBV、HCV双重感染发生HCC的合并优势比(OR)为50.27(95%CI:34.92~72.38)。结论:HBV、HCV感染是中国人群HCC高发的独立危险因素,HBV和HCV双重感染在HCC发生过程中呈协同作用。更多还原

【Abstract】 OBJECTIVE:To assess whether dual infection of hepatitis B virus(HBV)and hepatitis C virus(HCV)result in a higher risk of developing hepatocellular carcinoma(HCC)than each infection alone.METHODS:Literatures with case-control study were cited from CBM and Medline,and the data from the papers published from 1990 to 2006,which concerning the relationships between the dual infections of HBV/HCV with HCC in Chinese population,were selected and enrolled in the Meta-analysis.The pooled odds ratio(OR)and 95% confidence interval(95%CI)were calculated by random effect model.RESULTS:Totally 37 case-control studies with 4 203 cases and 5 642 controls separately were selected.As compared with the no-infecton,the pooled odds ratio and 95% confidence interval(CI)was 20.91(95%CI:15.40-28.40)for HBV infection alone,10.60(95%CI,6.74-16.65)for HCV infection alone,and 50.27(95%CI:34.92-72.38)for dual infections of HBV and HCV,respectively.CONCLUSION:Either HBV or HCV infections is the independent etiologic factor for HCC in China,and dual infection by HBV and HCV demonstrate synergism effect on the carcinogenesis of HCC.更多还原