【摘要】 目的探讨男性乙肝病毒(HBV)携带者对卵胞浆内单精子注射(ICSI)和常规体外受精(IVF)后胚胎结局的影响。方法根据男性血清乙肝表面抗原(HBsAg)是否阳性将359个ICSI周期和749个IVF周期分别分为两组:男性乙肝携带者组和对照组,比较两组的受精率、卵裂率、优质胚胎率、临床妊娠率和早期流产率。结果ICSI周期男性乙肝携带者组和对照组的受精率(分别为73.9%,71.5%)、卵裂率(分别为95.8%,94.4%)、优质胚胎率(分别为47.3%,47.1%)、临床妊娠率(分别为51.9%,43.9%)和早期流产率(分别为14.3%,15.7%)比较,差异无显著性意义(P均>0.05)。IVF周期男性乙肝携带者组和对照组的受精率(分别为7.07%,70.8%)、卵裂率(分别为94.2%,93.4%)、优质胚胎率(分别为43.6%,46.2%)、临床妊娠率(分别为39.0%,38.8%)和早期流产率(分别为14.0%,15.0%)比较,差异也无显著性意义(P>均0.05)。结论男性乙肝携带者不影响行ICSI和IVF后的治疗结果。更多还原

【Abstract】 Objective To investigate the effect of HBsAg-positive carrier males on the outcome of intracyto-plasmic sperm injection(ICSI)and in vitro fertilization(IVF)cycles.Methods 359 ICSI and 749 个 IVF cycles were divided into the HBsAg-positive carrier male and the control according to the presence of HBsAg in males’ serum respectively.The rates of fertilization,embryo cleavage,good quality embryos,clinical pregnancy and early abortion were compared among them.Results There was no significant difference between the HBsAg-positive carrier male and the control in the rates of fertilization,embryo cleavage,good quality embryos,clinical pregnancy and early abortion in ICSI and IVF cycles(73.9% vs 71.5%,95.8% vs 94.4%,47.3% vs 47.1%,51.9% vs 43.9%,14.3% vs 15.7% and 70.7% vs 70.8%,94.2% vs 93.4%,43.6% vs 46.2%,39.0% vs 38.8%,14.0% vs 15.0%,P>0.05).Conclusion The HBsAg-positive carrier males do not affect the outcome of ICSI and IVF cycles.更多还原