【摘要】 目的观察联合应用咪唑安定和异丙酚静脉浅麻醉在高龄患者胃镜检查治疗中的安全性。方法120例高龄病人(年龄(65岁)随机分为A B两组。A组采用咪唑安定联合异丙酚静脉浅麻醉(n=60),患者在胃镜检查治疗前静注咪唑安定(0.025-0.05)mg/kg和异丙酚(1-1.5)mg/kg,B组为常规检查对照组(n=60),仅口服10ml利多卡因胶浆,两组均持续监测MBP、HR、RR、SpO2、EKG的变化。结果A组60例均安静完成检查治疗,并在短时间内苏醒,检查中各指标与检查前无显著性差异(p>0.05),不良事件发生率3.3%;B组58例完成检查,监测指标与检查前有显著性差异(p<0.05),不良事件发生率18.33%。结论小剂量咪唑安定联合异丙酚静脉浅麻醉在高龄患者胃镜检查治疗中安全有效。更多还原

【Abstract】 Objective The aim of this study was to evaluate the safety of midazolam combined with propofol sedation for gastroscopy procedure in elderly patients.Methods 120 elderly patients(>65y) were divided randomly into 2 groups: group A(midazolam combined with propofol sedation,n=60) and group B(controls,n=60).In group A,midazolam(0.025-0.05)mg/kg was injected intravenously combined with propofol(1-1.5)mg/kg.In group B,only 10ml lidocaine plasma gel was administered orally.Heart rate(HR),blood pressure(BP),SpO2 and EKG were measured before the procedure and monitored constantly during and after the procedure.Results All patients in Group A showed obvious sedation during the procedure and became awake shortly after the procedure.There was no significant alterations(p>0.05) in cardiorespiratory monitoring parameters observed between intra-procedure and post-procedure.The rate of incident in group A was 3.3%;while in group B,only 58 patients completed the gastroscopy procedure.There was significant difference(p<0.05) in parameters monitored between intra-procedure and post-procedure.The rate of incident reached 18.33%.Conclusion Low dose midazolam in combination with propofol is an effective and safe method of sedation in gastroscopy procedures for elderly patients.更多还原