【摘要】 目的:检测人乳头状瘤病毒(HPV)在新疆哈萨克族食管癌及癌旁组织中的感染情况。方法:分别采用PCR法和原位杂交法检测60例食管鳞癌组织及相应癌旁正常鳞状上皮组织中HPV感染情况。结果:PCR和原位杂交检测食管癌组织中的HPV阳性率为51.7%和45%;正常食管癌癌旁组织中HPV阳性率为25%和15%。统计学结果显示食管癌组与癌旁正常鳞状上皮组中HPV感染,差异有统计学意义P<0.05。结论:新疆哈萨克族食管癌组织中存在HPV感染,HPV感染可能是其发病的危险因素之一。更多还原

【Abstract】 Objective: Detection of human papillomavirus in esophageal squamous cell carcinoma and its adjacent normal epithelium of Kazakh’s in Xinjiang.Methods:60 specimens of Xinjiang Kazakh’s esophageal squamous cell carcinoma and its adjacent normal epithelium were tested for HPV using polymerase chain reaction(PCR) and in situ hybridization(ISH).Results:Study were found HPV infection in esophageal squamous cell carcinoma,the positive rate were 51.7%and 45%;Normal esophageal squamous epithelium adjacent tissue HPV positive rate were 25% and 15%.Statistics showed that the experimental group and control group with significant statistical significance.Conclusion:About data suggestion that HPV is associated with Kazakh’s esophageal cancer in Xinjiang,HPV infection may be related to the occurrence of esophageal cancer.更多还原