【摘要】 小鼠采用非暴露式气管内注人法注入不同浓度多壁碳纳米管（MWNT）颗粒物悬液,在第10d 处死小鼠,并进行肺泡灌洗,测定肺泡灌洗液（BALF）中各项指标、肺脏器系数,并进行病理形态学观察.MWNT 10mg·kg^-1bw^-1组以上各指标均高于对照组和纳米1mg·kg^-1bw^-1组,差异显著（p<0.01或 P<0.05）;病理形态学观察结果表明,MWNT 10 mg·kg^-1bw^-1组小鼠肺部损伤最重.在实验条件下,MWNT 对小鼠肺造成急性损伤作用,对生物体健康构成潜在威胁,为研究 MWNT 对人体及环境的潜在性影响奠定实验基础.更多还原

【Abstract】 Animal models were worked out by injecting granule solution into the lung of rats through trachea.All rats were intratracheally instilled every three days.At the tenth day, all rats were sacrificed and their lungs were lavaged.The indexes in bronchoalveolar lavage flu- id were examined.Lung/body coefficient was measured.Morphological observations were pre- formed.All results of MWNT 10 mg·kg^-1bw^-1 group were obviously higher than the control group and the group of MWNT 1 mg·kg^-1bw^-1（P<0.01 or P<0.05）.The result of mor- phological observation indicated that the rats in MWNT 10 mg·kg^-1bw^-1 group had the supreme injury of lungs.Under this experimental condition,the effect of lung injury is more severity in MWNT.The study affords a foundation of research on the potential influence of MWNT to the human and environment.更多还原