Objective:To explore the characteristic of the expression of survivin gene in cervical cancer and study the clinical singnificance of survivin gene. Methods:Reverse transcription polymerase chain reaction(RT-PCR) and immunohistochemical SP method were used to determine the expression of survivin gene in 64 cervical cancer tissues, 17 CIN cervical tissues and 14 normal cervical tissues. The relationship between the expression and clinical pathology was analyzed. Results:The expression of survivin mRNA level ...
【更新日期】
2008-03-26
【分类号】
R737.33
【正文快照】
宫颈癌是女性常见的恶性肿瘤,其发病率及病死率在我国呈上升趋势,其发生、发展是一个多基因、多阶段的演进过程。survivin基因是近年新发现的凋亡抑制蛋白(inhibitor of apoptosis protein,lAP)家族成员之一,能抑制细胞凋亡、促进细胞增殖,与肿瘤的发生、发展有密切关系[1]。大
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