【摘要】 以2-甲基苯甲酸为原料,酰化后与氰化钠反应生成2-甲基苯甲酰腈,经甲酯化生成2-甲基苯甲酰甲酸甲酯,改进了三步合成2-甲基苯甲酰甲酸甲酯的方法,并对反应时间、反应温度等影响因素进行了优化,确定了合成反应中的最优化条件。同时对合成的目标化合物的红外光谱(IR)、气相色谱-质谱(GC-MS)和核磁共振氢谱(1H NMR)进行了解析,确证了该产物的合成。本方法具有合成产物分离简单、产率高等优点。更多还原

【Abstract】 2-methyl phenyl glyoxylate was prepared firstly by reaction of 2-methyl benzoyl chloride with NaCN.The reaction of 2-methyl phenyl glyoxylate with methanol gave the target product methyl 2-methyl phenyl glyoxylate.An improved 3 step synthetic method of methyl 2-methyl phenyl glyoxylate was studied.The optimization conditions were presented.The effect of reaction time and temperature on the yield was also discussed.Finally,the structure of the intermediates and product were identified by IR,1H NMR and GC-MS.2-methyl phenyl glyoxylate synthesized by improved methods was separated simply and had a high yield.更多还原