【摘要】 目的:检测特应性皮炎(AD)患者血中结合珠蛋白(Hp)表型和Hp基因频率的分布,并分析与病情严重程度之间的关系。方法:采用聚丙烯酰胺凝胶垂直平板电泳技术检测131例AD患者和134例正常对照者血中Hp表型的分布。结果:(1)不同病情严重程度患者之间的Hp表型及Hp基因频率分布无明显差别(P>0.05)。(2)患者组与对照组相比,Hp1-1和Hp2-1明显增高(P<0.05),Hp1基因频率明显增高(P<0.05)。(3)混合性AD组与单纯性AD组相比,Hp1-1和Hp2-1明显增高(P<0.05),Hp1基因频率明显增高(P<0.05)。结论:带有血清Hp2-1和Hp1-1的人群可能对AD有遗传易感性。Hp1基因在AD患者中有聚集现象,与其遗传易感性增高有某种内在联系,可能在AD发病中起一定作用。更多还原

【Abstract】 Objective: To investigate the distribution of serm haptoglobin phenotypes and gene frequency in atopic dermatitis(AD) patients and their relations with the severity of the disease.Methods: The distribution of haptoglobin phenotypes in the serum of 131 AD patients and 134 normal controls were determined by polyacrylamide gel vertical lat-bed electrophoresis.Results:(1) There was no significant difference between haptoglobin phenotypes and gene frequency among the AD patients with different severity of the disease(P>0.05).(2) Compared with normal controls,Hp1-1 and Hp2-1 were significantly increased in AD patient group(P<0.05).Hp1 allele was also higher(P<0.05).(3) Mixed AD patients showed increased frequency of Hp1-1,Hp2-1 and Hp1 allele,compared to pure AD patient(P<0.05).Conclusion: People with Hp1-1 and Hp2-1 may have genetic predisposition to AD.Hp1 allele frequency may assemble in AD patients and relate to the increased genetic predisposition of the disease,which may play a role in the pathogenesis of AD.更多还原