【摘要】 目的:探讨HLA-DRB1、DQB1位点基因与山东地区汉族寻常型银屑病的相关性。方法:用序列特异性引物-聚合酶链反应(PCR-SSP)方法,对98例山东汉族寻常型银屑病患者进行了HLA-DRB1、DQB1等位基因的分型,并分析了上述基因在各组中的分布。结果:寻常型银屑病患者组HLA-DRB1*07、DQB1*0201等位基因频率较正常对照组显著增高;I型寻常型银屑病HLA-DRB1*07、DQB1*0201等位基因频率较正常对照组显著增高;II型寻常型银屑病HLA-DRB1*10基因频率较正常对照组显著增高。结论:HLA-DRB1*07,HLA-DQB1*0201和HLA-DRB1*10可能是山东地区汉族寻常型银屑病的易感相关基因。更多还原

【Abstract】 Objective:To investigate the predisposing alleles of HLA-DRB1,DQB1 genes in psoriasis vulgaris.Methods:Polymerase chain reaction-specific sequence primers(PCR-SSP)method was used to type HLA-DRB1,DQB1 subregion in 98 cases of patients with psoriasis vulgaris and matched control subjects of Han nationality in Shandong province.Results:The frequency of HLA-DRB107,DQB10201 allele in patients with type I psoriasis vulgaris was significantly higher than that in controls.The frequency of HLA-DRB110 allele in patients with type II psoriasis vulgaris was significantly higher than that in controls.Conclusion:HLA-DRB107,HLA-DQB10201 and HLA-DRB110 may be the susceptible alleles of psoriasis in Han Shandong Chinese.更多还原