【摘要】 目的观察蕨麻多糖对CCl₄致急性化学性肝损伤的保护作用。方法60只昆明种小鼠按随机数字表分为6组,分别为正常对照组、CCl₄模型对照组、联苯双酯组、蕨麻多糖低、中、高剂量组（200、400、800 mg/kg）。给药7 d后用0.1%的CCl₄灌胃,建立实验性急性肝损伤模型,观察体重、脾脏系数、肝脏系数及血清中丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）活性。结果蕨麻多糖能明显降低CCl₄肝损伤小鼠血清中ALT、AST的活性（P<0.05）,且与剂量呈负相关。结论蕨麻多糖对小鼠CCl₄肝损伤有良好的保护作用。更多还原

【Abstract】 Objective To observe the effects of Potentilla anserina L.polysaccharide（PAP）on acute liver injury in mice.Methods 60 mice of Kunming species were randomly divided into 6 groups:control group,CC14 group（model-group）,bifendate group,low-dose（200 mg/kg of PAP）group,medium-dose（400 mg/kg of PAP）group,and high-dose（800 mg/kg of PAP）group. 0.1% CCl₄ solution was applied to establish acute liver injury model.The activities of serum ALT（alanine transaminase）,AST（aspartate amino transferase）in mice were tested individually in each group.Results PAP could dose-dependently decrease ALT and AST（P<0.05）.Con- clusion PAP has good protective effects on CCl₄-induced liver injury in mice.更多还原