【摘要】 目的探讨腺苷负荷心肌核素显像在冠心病诊断及介入治疗中的作用。方法冠心病的可疑患者,行腺苷负荷心肌核素显像,部分患者进行冠脉造影和介入治疗,介入治疗前后进行腺苷负荷心肌核素显像检查对比。腺苷负荷心肌核素显像采用单光子发射断层显像图像采集系统,腺苷总量为840μg/kg静脉泵入,3 min后静脉推注99mTc-MBI925 MBq,90 min后进行心肌断层显像,如果发现心肌显像异常,次日再行静息心肌显像。结果134例冠心病患者,年龄21~85(63.3±14.8)岁,男90例,女44例,进行腺苷负荷心肌核素显像,109例提示有心肌缺血现象,25例正常,诊断阳性率达81.3%。12例患者经过冠状动脉造影,有冠脉狭窄的患者行PCI,前后复查腺苷心肌核素显像,介入后心肌核素血流灌注较介入前明显改善(P<0.01)。结论腺苷负荷心肌核素显像在冠心病的诊断中起着重要的作用,其敏感性与特异性较高,同时在冠心病介入治疗前后疗效评价方面有一定的临床意义。更多还原

【Abstract】 objection To assess the accuracy of adenosine 99mTc-MIBI for the diagnosis of coronary artery disease and to evaluate the effect of adenosine 99mTc-MIBI myocardial perfusion SPECT in percutaneous coronary intervention(PCI).Methods Coronary angiography and adenosine 99mTc-MIBI myocardial perfusion SPECT were performed for all patients,After PCI.Adenosine was infused intravenously at a total 840 μg·kg-1 for 6 minutes,and 925MBq 99mTc-MBI was injected intravenously at 3 minutes after adenosine infusion.If the result was abnormal,rest 99mTc-MBI myocardial perfusion SPECT was performed next day.Results There were 134(63.3±14.8)cases with CAD.Adenosine myocardial perfusion imaging was abnormal in 109 cases out of 134 patients with significant coronary artery stenosis,in which 12 patients got PCI.Conclusion Adenosine myocardial perfusion imaging is an accurate method for detecting coronary artery disease and can be used in detecting regional myocardial perfusion abnormalities for patients with PCI.更多还原