【摘要】 目的探讨冠状动脉内注射地尔硫卓治疗直接经皮冠状动脉介入术(PCI)无复流的疗效。方法对23例直接PCI无复流患者给予梗死相关冠脉(IRA)内推注地尔硫卓2~4mg,分别于推注地尔硫卓前及推注后5min,用校正的心肌梗死溶栓治疗临床实验(TIMI)帧数(Corrected TIMI FrameCount,CTFC)评价IRA血流情况。结果23例无复流患者于IRA内注入地尔硫卓后CTFC由(60.45±12.10)帧降至(30.03±8.20)帧(P<0.001),其中17例(复流组)IRA血流恢复至TIMI3级,6例(无复流组)IRA血流未恢复,有效率73.91%。结论冠脉内注射地尔硫卓治疗直接PCI无复流能有效地恢复患者IRA血流,可作为治疗无复流的一种方法。更多还原

【Abstract】 Objective To assess the effect of intracoronary diltiazem on no-reflow phenomenon of the infarct-related artery (IRA) after emergency percutaneous coronary intervention (PCI) in patients with acute myocardial infarction. Methods 23 AMI patients with no-reflow phenomenon of IRA after emergency PCI were examined. All patients were given intracoronary diltiazem 2-4mg within 1 min. Five min later, coronary arteriography (CAG) was performed, and thrombolysis in myocardial infarction (TIMI) flow grade and corrected TIMI frame count (CTFC) were measured. Results The TIMI flow grade and CTFC improved significantly in all patients after intracoronary diltiazem therapy (P<0.001). Conclusions Intracoronary administration of diltiazem can effectively improve the no-reflow phenomenon after emergency PCI in patients with acute myocardial infarction.更多还原