【摘要】 目的:探讨原发性肝癌(PHC)患者血清血管内皮生长因子(VEGF)表达并分析与临床分期的关系。方法:采用ELISA法检测了45例PHC患者和30例正常对照组血清VEGF水平。结果:PHC患者组血清VEGF水平显著高于正常健康对照组(P<0.01)。PHC患者VEGF表达水平与肿瘤大小呈正相关性(P<0.01),TNMⅢ、Ⅳ期患者血清VEGF水平显著高于Ⅰ、Ⅱ期或者(P<0.01),PHC术后转移和复发患者血清VEGF也显著升高(P<0.01)。结论:PHC患者血清VEGF水平在一定程度上可反映肝癌发生、发展、转移情况及治疗效果。可能成为预测肝癌转移及疗效的有效指标。更多还原

【Abstract】 Objective:To detect the concentration of serum vascullar endothelial growth factor(VEGF)in primary hepatic carcinoma(PHC)and analyze the relation between VEGF and clinical stages.Methods:The serum VEGF in 45 patients with PHC,30 cases of normal control were determined by ELISA before and after treatment.Results:The serum VEGF levels in PHC group were siginficantly higher than those in control group(P<0.01).Serum VEGF showed a significant elevation in patients with remote metastasis,recurrent PHC and TNM Ⅲ、Ⅳ stages(P<0.01).The levels of serum VEGF in the patients with PHC were strongly associated with tumor size(P<0.01).Conclusion:The serum VEGF levels could reflect the condition of carcinogenesis,development metastasis and therapeutic efficay of the PHC and may predict the chance of metastasis and result of treatment.更多还原