【摘要】 目的了解原发性干燥综合征(pSS)合并自身免疫性甲状腺疾病(pSS-ATD)的临床特点。方法对279例原发性干燥综合征患者进行回顾性分析,探讨其合并自身免疫性甲状腺疾病的比例及临床特征。结果279例pSS患者中有82例合并有ATD,且患者临床表现多样,其中合并弥漫性毒性甲状腺肿(G raves病)8例占2.87%,合并甲状腺功能减退症56例占20.07%,两者比较差异有显著性意义(P<0.05);合并亚临床甲减18例占6.45%,与甲亢组比较,差异无显著性意义(P>0.05)。结论pSS可以合并多种自身免疫性甲状腺病,其中甲状腺功能减退症和亚临床甲减最常见。更多还原

【Abstract】 Objective To investigate the clinical features of autoimmune thyroid disease(ATD) involvement in primary Sjgren’s syndrome(pSS)[pSS-ATD].Methods The clinical data of 279 pSS patients in department of Rheumatology and Immunology,the first affiliated hospital of china medical university were retrospectively reviewed.Results There were a variety of clinical features presentations in pSS,in which 8 patients had Graves disease(GD) and 56 patients had hypothyroidism,accounting for 2.87% and 20.07% respectively,there are significant difference compared between GD and hypothyroidism(P<0.05).Eighteen(6.45%) of 279 pSS patients were subclinical hypothyroidism,there are no significant difference compared with GD(P>0.05).Conclusions A variety of autoimmune thyroid diseases(ATD) may be involved in pSS,in which hypothyroidism and subclinical hypothyroidism frequently occurrs in pSS.更多还原