【摘要】 目的探讨乳腺神经内分泌癌的临床及病理特征。方法自2005年4月至2008年6月收治女性乳腺神经内分泌癌7例。7例患者均进行综合治疗,并利用免疫组化法检测肿瘤细胞CgA、Syn、NSE、ER、PR、CerbB2、Ki67、p53的表达情况。结果7例均获随访,随访时间为7～45个月,平均22个月,均存活,无复发及远处转移。7例患者CgA和CerbB-2阳性率为71.4%(5/7);Syn、NSE、PR、Ki67阳性率为100%;ER阳性率85.7%(6/7);P53阳性率为14.3%(1/7)。结论乳腺神经内分泌癌是一类少见的特殊类型乳腺癌,神经内分泌标记物有助于该病的诊断及预后;综合治疗有利于提高该病患者的生存率,延长无病生存时间。更多还原

【Abstract】 Objective To investigate the clinical and phathologic characteristics of breast neuroendocrine carcinoma. Methods From Apr, 2005 to June, 2008, 7 cases with breast neuroendocrine carcinoma were analyzed retrospectively. There were 3 cases with stage Ⅰand 4 cases with stageⅡa in TNM classfication. All cases underwent combined treatment and CgA、Syn、NSE、 ER、PR、CerbB2、Ki67、p53 expression were detected by immunohistochemistry. Results All cases were followed-up average 22 months(range 7-45 months). All cases were alive with no recurrence and distant metastasis. Seven cases were positive for Syn、NSE、PR、Ki67,5 for CgA and CerbB-2, 6 for ER and 1 for P53. Conclusions Breast neuroendocrine carcinoma is a rare breast carcinoma. Neuroendocrine markers are useful for the diagnosis of breast neuroendocrine carcinoma. combined treatment is valuable for improving survival rate and prolonging sarvival time of diseas-free.更多还原