【摘要】 目的:研究骨髓增生异常综合征(MDS)患者骨髓单个核细胞线粒体呼吸链的功能变化并分析其与MDS的关系。方法:测定26例MDS患者与10例骨髓象正常者的单个核细胞线粒体呼吸链酶复合体Ⅰ、Ⅲ、Ⅳ的活性。结果:MDS患者呼吸链酶复合体Ⅰ、Ⅲ、Ⅳ的活性明显低于对照组(P<0.05);线粒体呼吸链酶复合体Ⅰ、Ⅲ的活性在RAEB-Ⅰ、RAEB-Ⅱ组与RA、RARS组的差异无统计学意义(均P>0.05),而酶复合体Ⅳ的活性在RAEB-Ⅰ、RAEB-Ⅱ组较RA、RARS组高,差异有统计学意义(P<0.05)。结论:线粒体呼吸链酶复合体的活性在MDS患者中降低,可能与MDS的病态造血及无效造血有关。更多还原

【Abstract】 Objective:To investigate the function of mitochondrial respiratory chain in bone marrow mononuclear cell(BMMNC)of myelodysplastic syndrome(MDS)and its relationship with MDS.Method:Activities of respiratory chain complexes Ⅰ,Ⅲ and Ⅳ were examined in BMMNC from 26 patients with MDS and 10 normal controls.Result:Activities of respiratory chain complexes Ⅰ,Ⅲ and Ⅳ in BMMNC were significantly lower in MDS patients than that in normal controls(P<0.05).According to WHO classification,activities of respiratory chain complexes Ⅰ、Ⅲ and Ⅳ in BMMNC were significantly lower in MDS RAEB-Ⅰ,RAEB-Ⅱ and RA,RARS than normal controls(P<0.05).Activities of respiratory chain complexes Ⅰ and Ⅲ in type RAEB-Ⅰ,RAEB-Ⅱ and type RA、RARS showed no significance difference(P>0.05),but the activities,of respiratory chain complexes Ⅳ was significantly higher in MDS RAEB-Ⅰ,RAEB-Ⅱ than RA,RARS(P<0.05).Conclusion:Reduced activities of respiratory chain complexes may be related to dysplastic hematopoiesis and ineffective hematopoiesis.更多还原