【摘要】 目的探讨视神经脊髓炎(neuromyelitis optica,NMO)患者人类白细胞抗原(HLA)-DPB1等位基因的多态性。方法采用基于测序的分型方法(sequence-based typing,SBT)分析13例NMO患者的HLA-DPB1等位基因的多态性。结果13例NMO患者中共检测到6种HLA-DPB1等位基因片段。HLA-DPB1*0501的频率显著高于HLA-DPB1*0201、HLA-DPB1*0202、HLA-DPB1*0301、HLA-DPB1*1301、HLA-DPB1*2101(P<0.05)。结论在NMO患者的HLA-DPB1等位基因多态性的研究中,HLA-DPB1*0501的频率显著高于其他,推测HLA-DPB1*0501可能与NMO的易患性有关。更多还原

【Abstract】 Objective To investigate the polymorphism of the HLA-DPB1 alleles in 13 neuromyelitis optica(NMO) patients.Methods The HLA-DPB1 allelic polymorphism of 13 subjects with NMO were determined by sequence-based typing(SBT).Results A total of 6 HLA-DPB1 alleles were identified in the 13 NMO subjects.The frequency of HLA-DPB10501 is markedly higher than HLA-DPB10201,HLA-DPB10202,HLA-DPB10301,HLA-DPB11301,HLA-DPB12101(P<0.05).Conclusion The frequency of HLA-DPB10501 is higher than others in the study of the HLA-DPB1 allelic polymorphism in NMO.It is infered that the susceptibility of NMO may be associated with HLA-DPB10501.更多还原