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甲钴胺对挤压伤大鼠坐骨神经的修复作用

Recovery Action of Methycobal to Sciatic Nerve Crush Lesion in Rats

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【Author】 SU Jian-Hua~1 ZHANG Li-Ping~1 CHEN Yu-Fang~2 TANG Jin-Rong~3 XIAO Hang~4 BAO De-Chen~1 1 Department of Neurology,The People’ s Hospital of Jintan,Jiangsu Jintan,213200; 2 Department of Histopathology,The Fourth People’s Hospital of Changzhou,Jiangsu Changzhou,213001; 3 Department of Neurology,The First Hospital Affiliated to Nanjing University of Medical Science,210029; 4 Institute of Toxicology and Neurology,Nanjing Universisty of Medical Science,Nanjing 210029,China

【机构】金坛市人民医院神经内科；常州市第四人民医院病理科；南京医科大学第一附属医院神经内科；南京医科大学应用神经毒理研究所；

【摘要】目的:观察甲钴胺对周围神经损害后恢复的影响。方法:以SD大鼠坐骨神经建立周围神经损害动物模型,以坐骨神经传导速度、坐骨神经干病理切片(光镜、电镜)为观察指标,考察甲钴胺对周围神经损害后恢复的影响。结果:甲钴胺组给药4周后能显著改善大鼠坐骨神经损害。结论:甲钴胺对周围神经损害有确切的修复作用。更多还原

【Abstract】 Aim:To study the recovery action of methycobal to peripheral nerve crush lesion in rats. Methods:Sciatic nerve crush lesion model was established in rats.The conduction velocity of sciatic nerve and the morphological changes were observed by light and electron microscope.Results:At the end of 4 weeks,methycobal can obviously recover the sciatic crush lesion in rats.Conclusion:Methycobal shows recovery effect on the peripheral crush lesion.更多还原

【关键词】甲钴胺；周围神经损害；修复作用；大鼠；
【Key words】 methycobal； sciatic nerve crush lesion； recovery action； rats；

【基金】江苏省常州市卫生局资助项目(编号：2004182)

【文献出处】中国临床神经科学 ,Chinese Journal of Clinical Neurosciences , 编辑部邮箱 ,2008年03期

【分类号】R964
【被引频次】15
【下载频次】152

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