【摘要】 目的探讨颈动脉粥样硬化斑块性质与血清C-反应蛋白(CRP)水平的关系。方法对经多层螺旋CT血管成像(MSCTA)检测发现有颈动脉粥样硬化斑块的28例脑血栓形成、24例腔隙性脑梗死、19例颈内动脉系统TIA患者进行CRP测定,分析斑块的性质与血清CRP水平的关系。结果(1)脑血栓形成组和TIA组以混合性斑块和软斑块为主,腔隙性脑梗死组以硬斑块为主;3组间斑块类型分布差异有统计学意义(均P<0.05);(2)血清CRP水平:脑血栓形成组为(4.022±1.531)mg/L,腔隙性脑梗死组为(3.781±1.876)mg/L,TIA组为(3.920±2.155)mg/L,3组间CRP水平差异无统计学意义(均P>0.05);(3)不同斑块组的CRP水平:软斑块组为(4.546±2.720)mg/L,混合性斑块组为(3.951±1.863)mg/L,显著高于硬斑块组[(2.762±1.323)mg/L](均P<0.05)。结论血清CRP水平对判断颈动脉粥样硬化斑块的稳定性具有一定临床意义。更多还原

【Abstract】 Objective To investigate the relationship of character of atherosclerotic plaque in carotid artery and serum CRP level. Methods The atherosclerotic plaques in carotid arteries were confirmed by multislice CT angiography(MSCTA),in which serum CRP level were detected in 28 patients with cerebral thrombosis,24 patients with lacunar infarction and 19 patients with TIA in internal carotid artery system in order to analysis the relationship between character of plaque and serum CRP level. Results (1)Mixed plaque and soft plaque were mainly found in cerebral thrombosis and TIA groups, while rigidity plaque was mostly found in lacunar infarction group, there were significance difference in plaques distribution among three groups(all P<0.05). (2)Serum CRP level in three groups (4.022±1.531)mg/L in cerebral thrombosis group,(3.781±1.876)mg/L in lacunar infarction group, (3.920±2.155)mg/L in TIA group respectively,there were no significant difference among three groups (P>0.05).(3) CRP level in different groups was (4.546±2.720)mg/L in soft plaque group, (3.951±1.863)mg/L in mixed plaque group respectively,those were both higher than that of the rigidity plaque group[(2.762±1.323)mg/L],and there was significance difference between them(all P<0.05). Conclusion There is a certain clinical significance for serum CRP level in estimating the stability of plaque in carotid artery.更多还原