【摘要】 目的观察银杏达莫注射液治疗急性脑梗死的疗效及对血液流变学和纤维蛋白原含量的影响。方法将96例急性脑梗死患者随机分为两组,银杏达莫组(39例)给予银杏达莫注射液20ml加入生理盐水500ml静脉滴注,对照组(57例)给予血塞通注射液10ml加入生理盐水500ml静脉滴注,均每天1次;连用14d。于治疗前后分别进行神经功能缺损程度评分(评价临床疗效)、血液流变学指标和纤维蛋白原含量的检测及头颅CT检查。结果银杏达莫组总有效率(94.9%)明显高于对照组(78.9%)(P<0.05),银杏达莫组治疗后血液流变学指标和纤维蛋白原含量比治疗前显著下降(均P<0.05)。银杏达莫组与对照组治疗后头颅CT病灶缩小或密度改善分别为25例(71.4%)、24例(49.0%),差异有统计学意义(P<0.05)。对照组全血黏度(30s-1)、红细胞压积比治疗前明显降低(均P<0.05),其他与治疗前差异无统计学意义。结论银杏达莫注射液治疗急性脑梗死效果明显,并能明显改善急性脑梗死患者的血液流变学指标,使纤维蛋白原含量下降。更多还原

【Abstract】 Objective To observe the curative effects of Ginkgo dipyridolum injection in the treatment of acute cerebral infarction and its influence on blood rheology and fibrinogen content.Methods 96 patients with acute cerebral infarction were randomly divided into two groups.39 patients in Ginkgo dipyridolum group were treated with 20 ml Ginkgo dipyridolum injection plus 500 ml saline intravenously,once a day.57 patients in control group were treated with Xuesaitong injection 10 ml plus 500 ml saline intravenously,once a day.All treatment lasted for 14 days.The score of neurological deficit was evaluated to assess the clinical efficiency,the changes of indexes of blood rheology,fibrinogen content and skull CT in the two groups were observed before and after treatment.Results Total effective rate(94.9%)in the Ginkgo dipyridolum group was signifcantly higher than that in the control group(78.9%)(P<0.05).Compared with those before treatment,the indexes of blood rheology and fibrinogen content in the Ginkgo dipyridolum group decreased significantly after treatment(all P<0.05).By the examination of CT,lesion diminution rates or density improve rates of the 2 groups were 71.4%(25 cases) and 49.0%(24 cases),respectively(P<0.05).Compared with those before treatment,whole blood viscosity 30s-1,hematocrit in the control group were signifcantly decreased(all P<0.05).However,other indexes were no difference before and after treatment.Conclusion Ginkgo dipyridolum injection is an effective drug for the treatment of acute cerebral infarction and can improve the indexes of blood rheology and decrease fibrinogen content.更多还原