【摘要】 目的探讨白塞病(BD)患者血浆血栓前状态分子标志物的变化,为临床早期发现并积极治疗BD合并血栓提供理论依据。方法诊断明确的BD患者32例(白塞病组)和对照组28例,分别用酶联免疫吸附法(ELISA)检测其血浆血管性血友病因子(vWF)、血小板α-颗粒膜蛋白-140(GMP-140)、凝血酶-抗凝血酶Ⅲ复合物(TAT)、交联纤维蛋白二聚体(D-Dimer)的水平,全自动血凝仪检测血浆纤维蛋白原(Fg)含量,并进行两组间的比较。结果与对照组相比,白塞病组血浆TAT、D-Dimer水平均明显升高(5.18±0.99比2.09±0.56)μg/L,P<0.01;(567.67±92.02比246.26±63.77)ng/ml,P<0.01),血浆vWF、GMP-140、Fg水平亦高于对照组(116.84±27.20比98.90±26.72)%,P<0.05;(12.42±3.98比10.16±3.42)μg/L,P<0.05;3.16±0.85比2.65±0.84,P<0.05)。结论白塞病患者存在着血栓前状态。更多还原

【Abstract】 Objective To evaluate the changes of the prethrombotic state molecular markers in patients with Behcet’s disease(BD).Methods The levels of plasma von Willebrand factor (vWF),platelet alpha-granule membrane protein-140 (GMP-140),thrombin-antithrombin complex(TAT),fibrin D-dimer (D-dimer),fibrinogen(Fg) from 32 BD patients and 28 normal controls were measured using enzyme linked immunosorbent assay (ELISA) and auto-instrument ACL-200 respectively.Results The levels of plasma vWF,GMP-140,TAT,D-dimer,Fg in the BD patients were significantly higher than in the normal controls (116.84±27.20 vs 98.90±26.72)%,P<0.05,(12.42±3.98 vs 10.16±3.42)μg/L,P<0.05,(5.18±0.99 vs 2.09±0.56)μg/L,P<0.01,(567.67±92.02 vs 246.26±63.77)ng/ml,P<0.01,(3.16±0.85 vs 2.65±0.84)g/L,P<0.05,respectively).Conclusion Prethrombotic state is present in patients with BD.更多还原