【摘要】 目的:分析先天性唇腭裂的发病情况及特点,为唇腭裂的预防提供临床资料。方法:对1433例先天性唇腭裂患者进行回顾性临床分析。结果:本组病例中,唇裂390例,唇裂伴腭裂794例,单纯腭裂249例;男性明显多于女性(2.35:1),但在不完全性腭裂中,女性多于男性(1:0.87);在单侧唇裂伴或不伴腭裂及完全腭裂中,左侧明显多于右侧(3.58:1);有家族遗传史的病例占总病例的6.35%;母亲妊娠初期经历危险因素316例,占22.05%;85.97%的患者来自农村;唇腭裂伴发其他畸型者42例,占2.93%。结论:多基因遗传与胚胎发育早期的环境因素是唇腭裂发病的重要因素。更多还原

【Abstract】 Objective:In order to know the clinical and deformity condition in patients with cleft lip and palate,further investigate related possible factors with cleft lip and palate,and provide clinical data for prevention to cleft lip and palate. Method:1433 patients with cleft lip and palate were analyzed statistically. Result:In these cases,there were cleft lip 390 cases(27.22%),cleft lip with cleft palate 794 cases(55.41%),and cleft palate 249 cases(17.38%).In all cases,males were more than females(2.35:1),but in uncomplete cleft palate,females were more than males(1:0.87).In cases of the unilateral cleft lip with or without palate and the complete cleft palate,the incidence of left side cleft was significant higher than that of the right side(3.58:1).A familial disposition was found in 91 of the 1433 families examined(6.35%).Mother underwent danger factors in the first three months of pregnancy:316 cases were found in 1433 cases(22.05%);85.97 % patients were from countrycide.42 cases had accompaning deformity(2.93%). Conclution:.It is suggested that the cleft lip and palate formation may be related with multiple genes and environmental condition in early stage of embryo.更多还原