【摘要】 目的:评价齐拉西酮治疗精神分裂症的疗效和不良反应。方法:80例精神分裂症患者,按入院顺序随机分为齐拉西酮组(40例)和利培酮组(40例)进行治疗6周观察。采用阳性与阴性症状量表(PANSS)评定疗效,用治疗中出现的症状量表(TESS)和锥体外系反应量表(RSESE)评定不良反应。结果:2药疗效相当。齐拉西酮组的锥体外系反应明显较少。结论:齐拉西酮为一种安全有效和耐受性较好的抗精神病药。更多还原

【Abstract】 Objective:To evaluate the efficacy and side effects of ziprasidone in treatment of schizophrenia.Method:According to hospitalization sequence,80 patients with schizophrenia were randomly divided into two groups,ziprasidone group(n=40)and resperidone group(n=40)were treated for 6 weeks.The efficacy and side effects were evaluated by positive and negative symptoms scale(PANSS)and treatment emergent symptoms scale(TESS)and rating scale for extrapyramidel side effects(RSESE)respectively.Results:The efficacy was similar for ziprasidone and risperidone.Extrapramidal side effects in patients of ziprasidone group were significantly fewer.Conclusion:Ziprasidone was a antipsychotic with better efficacy and tolerance and less side effects.更多还原