【摘要】 目的:以喉鳞状细胞癌为研究对象,探讨FHIT基因蛋白表达在喉癌发生、发展中的作用及临床意义。方法:用免疫组织化学SP法检测52例喉癌组织、23例癌旁组织及10例正常组织中FHIT基因蛋白的表达,分析在不同临床病理指标下FHIT蛋白表达的情况。结果:FHIT蛋白在正常组织中的阳性表达率(90.0%)及癌旁组织中的阳性率(78.3%)均高于癌组织中的阳性率(46.2%),差异有统计学意义(均P<0.01)。癌组织FHIT蛋白阳性表达率与临床分期和颈淋巴结转移有关,与病理分级无关。结论:喉癌的发生、发展与FHIT抑癌基因的失活有密切关系.FHIT基因很可能是喉癌重要的侯选抑癌基因。更多还原

【Abstract】 Objective:To investigate the role and clinical significance of the expression of FHIT gene in development and progression of laryngeal squamous cell carcinoma(LSCC).Method:The expression FHIT protein was detected by immunohistochemistry metheod in the 52 cases with LSCC and 23 cases of adjacent cancer tissues and 10 cases of laryngeal normal muscosa.The expression of FHIT was analyzed in LSCC with different clinicopathogical parameters.Result:The expression of FHIT in normal tissues(90.0%) and adjacent tissues(78.3%) was obvious higher than that in LSCC(46.2%),which had statistical significant difference(P<0.01).There was a positive correlation between FHIT expression and TNM staging,lymph node metastasis;but not pathological grade.Conclusion:The loss of FHIT expression may be correlated with the development and progression of laryngeal carcinoma.FHIT may be an important tumor suppressor gene in LSCC.更多还原