【摘要】 目的初步探讨Id3mRNA表达与乳腺浸润性导管癌(IDC)超声表现之间的关系。方法应用实时荧光定量RT-PCR检测36例IDC样本中Id3mRNA的表达,并与IDC超声表现对照分析。结果Id3mRNA在正常组织中的表达低于癌组织(P<<0.01)。IDC超声表现为毛刺征、周边导管扩张者Id3mRNA均呈高表达(P<0.01)。结论IDC声像图表现与病理组织学变化密切相关。IDC的二维超声征象可在一定程度上反应Id3mRNA的表达水平。更多还原

【Abstract】 Objective To investigate the relationship between the ultrasonic appearance of the breast infiltrating ductal carcino- mas(IDC)and the expression level of Id3mRNA.Methods The real-time fluorescent quantitative RT-PCR(RT-PCR)was used to detect the expression levels of Id3mRNA in 36 IDC.The results were compared with the ultrasonic features of IDC.Results The expres- sion of Id3mRNA was lower in normal tissues than that in carcinoma tissue(P<0.01).Id3mRNA had high expression in tissue with ul- trasonic appearance of spiculate margin and peripheral duct extension(P<0.01 ).Conclusion Ultrasonic appearance is closely related to pathology in IDC.The expression level of Id3mRNA can be assessed according to ultrasonic features of IDC in a certain extent.更多还原