【摘要】 目的探讨甘肃省金昌市学龄前儿童高铅血症现状及血铅水平与微量元素铜、锌、钒、铬、锰、钴、镓、锗间的相互关系。方法随机抽取金昌市部分幼儿园的256名儿童,用石墨炉原子吸收分光光度仪进行血铅、铜、锌、钒、铬、锰、钴、镓、锗含量的测定。结果①256名儿童血铅含量为28.30～268.00μg/L,平均(126.19±52.91)μg/L,其中>100μg/L者160名(占62.54%)。②钒、铜元素水平男高于女,差异有统计学意义(P<0.05、0.01);不同年龄组间锌、锗元素在6～7岁较2岁组降低,差异有统计学意义(P<0.01)。③铜元素在高血铅组较低血铅组增高,锌、锰、钴元素在高血铅组较低血铅组降低,差异均有统计学意义(P均<0.05)。④多元线性回归分析显示血铅与血锌、钴元素呈负相关。结论金昌市学龄前儿童高铅血症发生率高,应加强环境污染的治理,儿童应定期复查血铅水平,给予针对性的健康教育和营养指导。儿童高铅血症可导致血锌、锰、钴元素水平下降,血铜元素升高。更多还原

【Abstract】 Objectives To investigate the current status of high level of blood lead among preschool children in Jinchang of Gansu Province, and explore the correlation between blood levels of Pb and Cu, Zn, V, Cr, Mn, Co, Ga, and Ge. Methods Blood samples of 256 children (aged from 2 to 7 years), randomly selected from kindergartens in Jinchang were analyzed. Levels of Cu, Zn, V, Cr, Mn, Co, Ga, and Ge were measured with atomic absorption graphiteingle method. Results (1) The mean blood level of lead in 256 children was (126.19 ± 52.19) μg / L (28.30 μg /L to 268.00 μg/L), and there were 160 children (62.54%) with lead poisoning (the blood lead level > 100 μg / L). (2) The blood levels of Cu and V in the male were lower than those in the female, the differences were statistically significant (P < 0.05 and P < 0.01, respectively). The blood levels of Zn and Ge in the group of 2 - 3 years were low- er than those in the group of 6 - 7 years, the differences were statistically significant (P < 0.01). (3) The blood level of Cu was higher in the high blood lead group than that of low blood lead group; the difference was statistically significant (P < 0.05) . The blood levels of Zn, Mn, and Co were lower in the high blood lead group than those in the low blood lead group; the differences were statistically significant (P < 0.05 and P < 0.01, respectively). (4) Linear regression analysis between Pb and other trace elements showed that Pb level negatively correlated to Zn and Co levels. Conclu- sions The incidence of raised blood level of lead was high in Jinchang city. The management of environment pollution, timely determination of Pb-B in children, and pertinent delivery of health education and nutrition guidance for children should be strengthened. High blood level of lead may result in lower blood levels of Zn, Mn, or Co and increase of blood Cu level.更多还原