【摘要】 目的:探讨口腔黏膜癌浸润前沿分级、细胞增殖核抗原和Ki67抗原在浸润前沿中的表达及意义。方法:对30例原发口腔黏膜癌进行分级,采用免疫组化SP法分别检测浸润前沿和中心PCNA、Ki67的表达。结果:口腔黏膜癌浸润前沿(ITF)和非前沿WHO(1997)分级差异有显著性(P<0.05);浸润前沿PCNA(P<0.01)、Ki67(P<0.05)的表达均高于非前沿部分,差别有显著性;浸润前沿PCNA标记指数(LI)(P<0.05)与浸润前沿分级(IFG)总分呈正相关关系。结论:口腔黏膜癌浸润前沿肿瘤细胞分化较差,增殖活性明显高于非前沿部分。在浸润前沿中PCNA和Ki67的高表达可以反映肿瘤的高恶性度及高复发转移倾向。更多还原

【Abstract】 Objective: To study the expression and significance of the invasive front grading(IFG),proliferating cell nucler antigen(PCNA) and Ki-67 antigen in the invasive tumor front(ITF) of oral mucosa carcinoma.Methods: Thirty samples of oral mucosa carcinoma were graded by using IFG.The expression of PCNA and Ki67 were evaluated at the ITF and the other parts of the same tumor by the immunohistochemical technique(SP method).Results: There were significant difference in the invasive tumor front(ITF) and the center of oral mucosa carcinoma about the WHO(1997) grading(P<0.05).The expression of PCNA(P<0.01) and Ki67(P<0.05)at the ITF were higher than those of other parts.The IFG score was significantly correlated with the expression of PCNA(P<0.05).Conclusion: The ITF of oral mucosa carcinoma differentiates poorerly than the other parts and is active in proliferation.The higher levels of PCNA and Ki-67 may indicate the trend of higher malignant,recurrence and metastasis.更多还原