【摘要】 目的探讨甲状腺功能亢进症导致肝损伤的临床相关因素.方法回顾性分析我院1980年1月至2006年12月收治的甲亢患者755例,其中甲亢性肝损伤200例(A组),555例单纯性甲亢(B组),比较两组患者的年龄、性别、病程以及甲状腺功能与肝功能.结果(1)甲亢导致肝损伤的发生率26.49%;(2)甲亢年龄越大,肝损伤的发生率越高(P<0.05);(3)肝损伤的发生率与甲亢患者性别无关(P<0.05);(4)甲亢性肝损伤与甲亢病程密切相关(P<0.01);(5)甲亢性肝损伤患者血清TT3、TT4、FT3、FT4明显高于单纯性甲亢(P<0.01),而血清TSH则明显比单纯性甲亢低(P<0.05);(6)1980年～2006年我院甲亢以及甲亢性肝损伤的发生率有升高的趋势.结论甲亢容易导致肝损伤,甲亢并肝损伤与甲亢患者的年龄、病程和病情密切相关,而与性别无关.我院甲亢性肝损伤的发生率有升高的趋势.更多还原

【Abstract】 Objective To analyze the clinical relative factors of hyperthyroidism leading to liver damage. Methods Clinical history of 200 cases of hyperthyroid with liver damage(group A)and 555 cases without liver damage(group B)were reviewed from January 1980 to December 2006. Results (1)The incidence of liver damage accompanied with hyperthyroid was 26.49%;(2)The older was the hyperthyroidism patient, the higher was the incidence of liver damage(P<0.05);(3)The incidence of liver damage was not correlated with gender of hyperthyroidism patient(P>0.05);(4)The liver damage was significantly correlated with the course of hyperthyroidism(P<0.01);(5)The serum levels of TT3,TT4,FT3 and FT4 in hyperthyroid patients with liver damage were significantly higher,but the serum levels of TSH were remarkably lower than that in the patients without liver damage(P<0.01);(6)The incidence of hyperthyroid and the hyperthyroidism leading to liver damage was increased in our hospital from 1980 to 2006 Conclusions Patients with hyperthyroidism are susceptible to liver damage. The seriousness of liver damage is significantly correlated with age, course and seriousness of hyperthyroidism. The incidence of hyperthyroid and the hyperthyroidism leading to liver damage has the tendcy to increase.更多还原