【摘要】 目的考察槐定碱白蛋白微球的不同制备工艺条件对其体外释药特性的影响。方法以酸性染料比色法测定槐定碱的含量。绘制不同条件下制备的微球的累积释放曲线,并用相似因子法进行分析。结果不同固化温度下所制备的微球的释药曲线的f2值差异性较大。随着固化温度的升高,微球的释药速度减慢。结论固化温度对槐定碱白蛋白微球释药影响较大,通过调节固化温度可以制备出释放速度合格的微球。更多还原

【Abstract】 Objective To investigate the influence of preparation conditions on the release of sophoridine-BSA-microspheres(SR-BSA-MS)in vitro.Methods The content of SR was determined by using acid dye colorimetry.The accumulative release curves of SR-BSA-MS under different preparation conditions were made and analyzed by similarity factor method.Results The f2 values of the release curves of SR-BSA-MS under different solidified temperatures had great difference.The release of SR-BSA-MS slowed down when the solidified temperature was raised up.Conclusion Solidified temperature was the most important factor for the release of SR-BSA-MS in vitro.The satisfactory release profile of SR-BSA-MS in vitro can be got through regulating solidified temperature.更多还原