【摘要】 目的探讨阿托伐他汀对不稳定型心绞痛(UAP)患者脂联素以及其他炎性指标的影响。方法48例UAP患者随机分成常规组和阿托伐他汀组,常规组使用常规药物治疗,阿托伐他汀组在常规治疗基础上加用阿托伐他汀20mg/d,均治疗2周,分别于治疗前和治疗后2周抽血测定脂联素及其他相关指标。同时设45例健康人群作为健康对照组。结果与健康对照组相比,UAP患者的血清脂联素显著降低,而炎性反应因子超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)显著升高。治疗后阿托伐他汀组和常规组hs-CRP、TNF-α、IL-6均下降,但阿托伐他汀组治疗后较常规组明显下降(P<0.05)。阿托伐他汀组治疗后血清脂联素明显升高。结论阿托伐他汀治疗能降低UAP患者hs-CRP、TNF-α、IL-6水平,有助于纠正UAP患者的炎性反应因子水平。更多还原

【Abstract】 Objective To investigate the effect of atorvastatin on serum adiponectin and other inflammatory indices in patients with unstable angina.Methods Forty-eight patients with unstable angina were randomly divided into two groups:convention group(treated with conventional therapeutic drugs)and atorvastatin group(besides conventional therapeutic drugs,given atorvastatin 20 mg per day for two weeks).Serum adiponectin and correlated indices were measured before and after 2 weeks’ intervention.Forty-five healthy people were enrolled as controls(control group).Results Compared with those of healthy controls,serum adiponectin levels in UAP patients were significantly lower(P<0.01)and levels of hs-CRP,TNF-α and IL-6 were higher(P<0.05).After 2 weeks of treatment,the levels of hs-CRP,TNF-α and IL-6 were decreased in both convention group and atorvastatin group,but the levels of above indices were more declined in atorvastatin group.The patients in atorvastatin group had lower levels of hs-CRP,TNF-α and IL-6 and higher levels of serum adiponectin compared with control group(P<0.05).Conclusion Atorvastatin can decrease the levels of hs-CRP,TNF-α and IL-6 in UAP patients,which exerts beneficial effects on the above inflammatory factors.更多还原