【摘要】 目的:探讨中草药治疗慢性尿酸性肾病的疗效及安全性。方法:用计算机对网上电子数据库和手工对参考文献进行检索有关中草药治疗尿酸性肾病的临床试验、系统综述和荟萃分析。结果:共有12项随机临床试验符合标准而纳入研究。8项(67%)试验涉及9个(75%)中草药单用或与降尿酸西药联用显示治疗尿酸性肾病有明显疗效。其中6种(75%)中草药(滋肾汤、化湿泄浊祛瘀汤、降尿酸方、补肾化湿通络汤、活血泄浊汤、痛风1号)加用西药有显著疗效。3种(60%)中草药(威草胶囊、痛风合剂、痛风1号)单用有显著疗效。所有试验均为低质量试验。倒漏斗图形显著不对称,提示存在发表偏畸。结论:本系统综述显示某些中草药单用或与西药联用治疗痛风性肾病有具有一定的疗效,亦无发生严重毒副作用的报道。但由于所纳入试验方法学质量低下等原因,推荐中草药用于治疗痛风性肾病的证据强度不大。其潜在的疗效及安全性还需严格设计的高质量的随机双盲对照试验加以证实。更多还原

【Abstract】 Objective:This systematic review is conducted to explore the efficacy of CTM(TCM)in treating urate nephropathy.Methods:A computer and manual searched for randomized controlled trials in treating urate nephropathy patients with TCM,meta-analysis,and systematic review from internet electric databases and reference was performed.Results:A total of 12 studies met the inclusion criteria.A meta-analysis of these 8 studies(67%)involving 9 arms(75%)showed that CTM used alone or combined with other western medicine had significant benefit in urate nephropathy.Among these studies,Six CTMs(75%):Zishen decoction,Huashi xiezhuo quyu decoction,Jiangniaosuan decoction,Bushen huashi tongluo decoction,Huoxie xiezhuo decoction,Tongfang No.1 combined with western medicine had the effectiveness over western medicine.Three CTMs(60%):WeiCao capsule,Tongfong mixture,Tongfang No.1 showed benefit for urate nephropathy over western medicine.All of these studies were low quality studies.Funnel plot was asymmetry;it indicated presence of publication bias.Conclusion:Although some TCMs used alone or combined with other western medicine had therapeutic benefit in urate nephropathy in our studies,the evidence is not strong to recommend it for treatment of urate nephropathy due to the low quality studies.It is necessary to conduct rigorous well-designed clinical trials to evaluate their efficacy and safety for ruate nephropathy treatment.更多还原