【摘要】 目的探讨泰兴市原发性肝癌的家庭聚集性。方法采用病例对照家系设计收集家系资料,应用边际回归模型方法分析亲属间肝癌的家庭相关大小和模式。结果肝癌病例的亲属比对照亲属有更高的疾病风险。调整了乙肝表面抗原后,亲属间的相关不再有统计学意义。结论边际回归模型可用于家系资料,研究表明肝癌存在家庭聚集性,HBV感染在肝癌的家庭聚集性中起着很重要的作用。更多还原

【Abstract】 Objective To explore the familial aggregation of HCC in Taixing.Methods We applied case-control family design to measure the familial correlation using marginal regression model.Results The relatives of case had higher disease risk than ones of the control.When HBsAg was adjusted,the association parameters among relatives were no longer statistically significant.Conclusion Marginal regression model could be used for family data.HCC had familial aggregation and HBV infection played an important role in familial aggregation of HCC.更多还原