【摘要】 目的探讨在强迫症患者、精神分裂症患者、正常对照人群中,眼球轨迹运动各指标的差异。方法应用眼球轨迹运动标记记录仪(MODELIV日本提供)对符合国际疾病分类第10版和中国精神障碍分类与诊断标准第3版(CCMD-3)的相应诊断标准的103例强迫症患者、81例精神分裂症患者及81例正常对照人群进行测试,用判别式分析结果,获得正分为精神分裂症患者,获得负分为非精神分裂症患者。比较眼球轨迹运动在强迫症患者、精神分裂症患者以及正常对照人群组的组间差异。结果103例强迫症患者获正分52例(50.5%),负分51例(49.5%),强迫症患者对D分值的特异性49.5%,81例正常人群对照组正分7例,负分74例,D分值特异性91.4%,精神分裂症患者组81例,正分67例(82.7%),负分14例(17.3%),对D分值敏感性82.7%,D分值、EETM在正常对照人群与精神分裂症组间比较其差异有非常显著性(P<0.01);D分值、EETM在强迫症与正常人对照组比较除MESL外,其它指标差异有非常显著性(P<0.01),D分值、EETM在精神分裂症组与强迫症组比较除NEF外,其它指标差异有非常显著性(P<0.01)。结论精神分裂症患者眼球轨迹运动的敏感性较高,探究性眼球轨迹运动检查不仅可作为对精神分裂症的辅助诊断工具,并为临床排除非精神分裂症性障碍提供重要的参考依据,探究性眼球轨迹运动异常可能反映部分强迫症生物学特征。更多还原

【Abstract】 Objective:To observe the difference of exploratory eye tracking movements(EETM)in patients with obsessive-compulsive disorder,schizophrenia and normal controls.Methods:One hundred and three patients with obsessive-compulsive disorder,81 schizophrenia patients and 81 normal controls were tested by tracking of exploratory eye movement(Type-Ⅳ).According to discriminant analysis,the result "positive" is as schizophrenia patients and "negative" is as non-schizophrenia patients.Results:Fifty two(50.5%)of the 103 patients with obsessive-compulsive disorder were positive at discriminant analysis and fifty one negative,with specificity of discriminant analysis 49.5%.In 81 normal controls,7 cases were positive result and 74 cases were negative,with specificity of discriminant analysis 91.4%.In 81 schizophrenia patients,67 cases were positive and 14 cases were negative,with sensitivity of discriminant analysis 82.7%.The results of discriminant analysis and EETM were statistically different between schizophrenia patients and normal controls(P<0.01).Significant differences were noted in indices except mean eye scanning length(MESL)between obsessive-compulsive disorder patients and normal controls(P<0.01);and significant differences were noted in indices except number of eye fixation(NEF)between obsessive-compulsive disorder and schizophrenia patients(P<0.01).Conclusion:The sensitivity of exploratory eye tracking movement test in schizophrenia is high.It can help to differentiate diagnosis of schizophrenia and non-schizophrenia.Exploratory eye tracking movement may be biological marker of schizophrenia.更多还原