【摘要】 制备以聚乙烯吡咯烷酮为载体的阿霉素纳米粒,研究纳米粒在生理盐水中的释放行为,并采用不同数学模型模拟。结果表明,制备的阿霉素纳米粒粒径小,球形度好;体外释放结果表明阿霉素纳米粒具有缓释特性,且双相动力学方程能模拟阿霉素纳米粒在生理盐水中的释放行为。更多还原

【Abstract】 Doxorubicin-loaded nanoparticles,using doxorubicin(ADM)as model drug,polyvinylpyrrolidone(PVP)as matrix material, were prepared in this paper.From the observation of SEM,the nanoparticles exhibited a spherical shape.Dialysis method was used to test the property of nanoparticles in vitro release.Several mathematical models of drug release,such as zero order equation,first order equation,Higuchi and double exponential diphase kinetics equation,were used to fit the vitro release of NP.The double exponential diphase kinetics equation included a concussion phase and a slow-release phase.The simulation results showed that it could fit better drug release of nanoparticles in Physiological Saline.更多还原